Staining ILM With a Mixture of BBG and Sodium Hyaluronate
Staining ILM With a Mixture of BBG and Sodium Hyaluronate
Mixing the BBG with a dextrose solution or with deuterium oxide can create a solution of high specific gravity. But the physicochemical properties of visco-BBG are not only high specific gravity but also high elasticity, viscosity and surface tension. Moreover, the visco-BBG had the same optical properties as the vitreous and is not toxic or allergenic. Thus, the visco-BBG can be 'poured' onto the retina rather than streaming it against the retina due to its heavy specific gravity. In addition, it will not diffuse throughout the vitreous cavity and stain the selective area of the ILM which is intended to be peeled because of its cohesive property and higher surface tension. In addition, the visco-BBG will not disperse into the subretinal space due to its high surface tension. Therefore, it is a safer and better intraoperative adjuvant than the usual BSS-BBG for macula surgery.
We had the impression that the staining effects of visco-BBG are equal or better than BSS-BGG. It seems reasonable to assume that the visco-BBG will remain in the retinal surface (see online supplementary video 4) due to its high surface tension and high specific gravity, resulting in a better visualisation of the ILM.
In summary, our findings show that visco-BBG can be managed in a very controlled way over the intended region without spraying. In addition, it will not disperse and will remain in the intended region. Thus, we recommend visco-BBG be used for ILM peeling due to its safety and ease of intraoperative use.
Discussion
Mixing the BBG with a dextrose solution or with deuterium oxide can create a solution of high specific gravity. But the physicochemical properties of visco-BBG are not only high specific gravity but also high elasticity, viscosity and surface tension. Moreover, the visco-BBG had the same optical properties as the vitreous and is not toxic or allergenic. Thus, the visco-BBG can be 'poured' onto the retina rather than streaming it against the retina due to its heavy specific gravity. In addition, it will not diffuse throughout the vitreous cavity and stain the selective area of the ILM which is intended to be peeled because of its cohesive property and higher surface tension. In addition, the visco-BBG will not disperse into the subretinal space due to its high surface tension. Therefore, it is a safer and better intraoperative adjuvant than the usual BSS-BBG for macula surgery.
We had the impression that the staining effects of visco-BBG are equal or better than BSS-BGG. It seems reasonable to assume that the visco-BBG will remain in the retinal surface (see online supplementary video 4) due to its high surface tension and high specific gravity, resulting in a better visualisation of the ILM.
In summary, our findings show that visco-BBG can be managed in a very controlled way over the intended region without spraying. In addition, it will not disperse and will remain in the intended region. Thus, we recommend visco-BBG be used for ILM peeling due to its safety and ease of intraoperative use.
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